Immunologic Memory Of Phytohemagglutinin-Stimulated Lymphocytes
نویسندگان
چکیده
منابع مشابه
Immunologic memory of phytohemagglutinin-stimulated lymphocytes.
By JEROME I. BRODY AND HENRY D. SOLTYS T HE PUBPOSE of this study was to delineate the durability and persistence of immunologic recall in the normal peripheral blood lymphocyte using methods which might reflect the importance of the manner by which imniunologic information is acquired. This was done in the present investigation with the technic of bacterial adherence,”2 in which circumferentia...
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I T HAS BEEN SHOWN that peripheral i)lood lynlphocvtes undergo trainsformation and mitosis in vitro when cultured in the presence of plwtohemagglutinin ( PHA).’4 Little information has been reported on the numl)er of lymphocytes which survive and transform during the culturing interval. It has been very difficult to enumerate lymphocytes in cultures containing PFIA I)ecause the agglutinated ery...
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The association of a human genetic deficiency of adenosine deaminase activity with combined immunodeficiency prompted a study of the effects of adenosine and of inhibition of adenosine deaminase activity on human lymphocyte transformation and a detailed study of adenosine metabolism throughout phytohemagglutinin-induced blastogenesis. The adenosine deaminase inhibitor, coformycin, at a concentr...
متن کاملCharacterization of DNA excreted from phytohemagglutinin-stimulated lymphocytes
The DNA released into the culture medium after phytohemagglutinin (PHA) stimulation of human peripheral blood lymphocytes has been purified and characterized. It is double stranded, sediments at 7-8S in alkaline sucrose, and has a Tm determined optically and by thermal elution from hydroxyapatite that is substantially lower than that found for lymphocyte cell DNA. Media DNA contains a major com...
متن کاملInhibition of mitosis by chloramphenicol in phytohemagglutinin stimulated lymphocytes.
I TARIOUS CLINICAL AND EXPERIMENTAL STUDIES have shown V that chioramphenicol ( CAP) affects cell division. #{176} The characteristic aplastic marrow that is seen when toxicity is fully expressed suggests a toxic effect leading to depletion of dividing cells. The effect of CAP on incorporation of 32 into phytohemagglutinin ( PHA) stimulated lymphocytes was reported by McIntyre and Ebaugh,’ who ...
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ژورنال
عنوان ژورنال: Blood
سال: 1969
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v34.6.765.765